FAK ligand-5
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
FAK ligand-5 is a FAK ligand. FAK ligand-5 can be coupled with a linker to synthesize BI-4464. FAK ligand-5 can be used as a target protein ligand for PROTAC development, specifically for designing PROTAC FAK degraders. FAK ligand-5 can be used in the synthesis of PROTAC FAK degrader 4 (HY-178467). FAK ligand-5 can be used in cancer research[1].
1227948-58-4
12352005
H302-H315-H319-H335
FAK; Ligands for Target Protein for PROTAC
PROTAC; Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
O=C(O)C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC(CC4)=C3C4=O)=N2)C(OC)=C1
C22H16F3N3O5
459.37
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation. Bioorg Chem. 2025 Oct;165:109017.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-43760/
Reference compound2
No Development Reported
Beschrijving
FAK ligand-5 is a FAK ligand. FAK ligand-5 can be coupled with a linker to synthesize BI-4464. FAK ligand-5 can be used as a target protein ligand for PROTAC de
Specificaties
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