FAM193B Antilichaam

FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.

54540

Q96PV7

Q96PV7

Human

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

FAM193B Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (81%)

FAM193B Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FAM193B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

99 kDa

IgG

At least two isoforms of FAM193B are known to exist; this antibody will detect both isoforms.

FAM193B

Cat. No. 17-005 - Jurkat Cell Slide

Family with sequence similarity 193, member B

Homo sapiens

Picchione F, Pritchard C, Lagutina I, et al. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS) . Carcinogenesis 2011; 32:452-62.

Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008; 270:10-8.

FAM193B Antibody: IRIZIO, KIAA1931, Protein FAM193B

ELISA, WB, IF

205831282

Liquid