FAR1 Antilichaam

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727) . A pseudogene of this gene is located on chromosome 13.

84188

Q8WVX9

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human FAR1 (NP_115604.1) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

WB: 1:500 - 1:2000

FAR1

Fatty acyl CoA reductase 1

Homo sapiens

MLSTD2, DKFZp686A0370, DKFZp686P18247, FAR1, FLJ22728, FLJ33561, MLSTD2, SDR10E1

WB

Liquid