FARS2 Antilichaam - N-terminaal gebied : HRP (ARP40669_T100-HRP)

Phenylalanyl-tRNA synthetase 2, mitochondrial

FARS1, PheRS, SPG77, COXPD14, HSPC320, mtPheRS

10667

O95363

NP_006558

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human FARS2

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS2 is a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta) 2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS1 encodes a mitochondrially-located phenylalanine-tRNA synthetase (PheRS) which consists of a single polypeptide chain unlike the (alpha-beta) 2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and the eukaryotic cytoplasm.

TRIM27; KRT31; KRT13; RCBTB2; NOTCH2NL; KRTAP10-3; KRTAP10-5; KRTAP10-9; KRTAP10-7; KRT40; CMTM5; HMBOX1; TRIM54; AGTRAP; ADAMTSL4; APPL1; IKZF3; MID2; CALCOCO2; STX11; MKRN3; TFCP2; TADA2A; SUMO1; UBC; NEDD8; CUL3; ISG15; ICT1; USP45; G3BP2

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 93%; Dog: 92%; Guinea Pig: 85%; Horse: 83%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

50kDa

Brandenberger, R., (2004) Nat. Biotechnol. 22 (6), 707-716

Wet Ice

451

FARS2

FARS2

Rabbit

Phenylalanine--tRNA ligase, mitochondrial

NM_006567

VELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQ