FAS-antilichaam

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD) . The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

355

P25445

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FAS (NP_000034.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Neuroscience

Affinity purification

Mouse liver

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 38kDa

IgG

FAS

Fas cell surface death receptor

Homo sapiens

CD95; APO-1; TNFRSF6; Tumor Necrosis Factor Receptor Superfamily Member 6; Apoptosis-mediating Surface Antigen FAS

WB, IHC

Liquid