FAS-antilichaam

Tumor necrosis factor receptor superfamily, member 6 isoform 1; apoptosis antigen 1; Fas antigen; APO-1 cell surface antigen. This protein is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-κ B, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. ** Cat.N

355

P25445

NP_000034.1

Human, Mouse, Rat

21-165

Unconjugated

Primary Antibodies

Apoptosis, Neuroscience

Antigen affinity-purified

1 mg/mL

Phosphate-Buffered Saline. No preservatives added.

None

Blue Ice

FAS antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

37.7 kDa (calculated)

FAS (N-145) antibody can be used for the detection of FAS (N-145) by Western blot, may also work for IHC and ICC.

FAS

Fas cell surface death receptor

Homo sapiens

Brunner, T. et al : Cell-autonomous Fas (CD95) /Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373: 441-444, 1995.

APT1, FAS1, TNFRSF6, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, APT1, CD95, APO-1, FASTM, ALPS1A, RP11-399O19.9, FAS (N145)

WB

4507583

Liquid