Fas Ligand Antilichaam

Fas Ligand is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane mediated apoptosis. Ligation of Fas by Fas Ligand or an anti Fas cross linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas Ligand system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumors. Tumor cells frequently exhibit de novo expression of Fas Ligand, which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas Ligand system.

356

P48023

P48023

Human

Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hFasL (human FAS Ligand) .

Unconjugated

Primary Antibodies, Functional Antibodies, Antibody Pairs

Apoptosis

Anti-hFasL specific antibody was purified by affinity chromatography employing immobilized hFasL matrix.

Batch dependent

None

Room Temp

Fas Ligand antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

FASLG

Fas ligand (TNF superfamily, member 6)

Homo sapiens

APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL

ELISA, WB, Neutralization Assay

1345957

Lyophilized