FBXW8 Antilichaam - middengebied: HRP (ARP55585_P050-HRP)

F-box and WD repeat domain containing 8

FBW6, FBW8, FBX29, FBXW6, FBXO29

26259

Q8N3Y1

NP_699179

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human FBXW8

FBXW8 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW8 contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class.This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

MAP4K1; CUL1; TBC1D3; CUL7; UBE2D3; SKP1; IRS1; REST; CCND1; CUL4A; DDB1; UBC; CCDC8; GORASP1; OBSL1; CCT6B; CCT2; CCT7; TRIP13; PDCD5; CUL2; VBP1; CCT3; PFDN5; NFKBIA; CCT6A; BCL3; BTRC; SKP2; HSP90AA1; HSPA4; FBXO4; FBXW8; FBXW2; MYC; RBX1; UBI4; EP300

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 83%; Dog: 92%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

67kDa

Tsutsumi, T., (2008) Mol. Cell. Biol. 28 (2), 743-751

Wet Ice

598

FBXW8

FBXW8

Rabbit

F-box/WD repeat-containing protein 8

NM_153348

MNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHR