FEN1 Mouse Monoclonal Antibody [Kloon ID: LBI2B2]

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) FEN1 mouse monoclonal antibody, clone LBI2B2

FEN-1; MF1; RAD2

Homo sapiens flap structure-specific endonuclease 1 (FEN1), mRNA.

2237

P39748

Unconjugated

Base excision repair, DNA replication, Non-homologous end-joining

Base excision repair, DNA replication, Non-homologous end-joining

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Stem cell - Pluripotency

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

FEN1

https://www.ncbi.nlm.nih.gov/gene/?term=2237

https://www.uniprot.org/uniprot/P39748