Fenofibrinezuur-13C8

Fenofibric acid-13C8 (FNF acid-13C8) is 13C labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.

FNF acid-13C8

12352211

COX; Isotope-Labeled Compounds; PPAR

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Metabolism-protein/nucleotide metabolism

Metabolic Disease

O=C(C([13CH3])([13CH3])O[13C]1=[13CH][13CH]=[13C](C(C2=CC=C(C=C2)Cl)=O)[13CH]=[13CH]1)O

C9 13C8H15ClO4

326.69

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Dietz M, et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7 (6) :1101-11.|[3]Prasad GS, et al. Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology. 2017 Dec 13.|[4]Neumeier M, et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun. 2006 Nov 24;350 (3) :731-5. Epub 2006 Sep 27.|[5]Miranda S, et al. Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. J Cell Physiol. 2012 Jun;227 (6) :2352-62.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0760S1/

Isotope-Labeled Compounds

No Development Reported