Fenofibrinezuur-d4
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Fenofibric acid-d4 (FNF acid-d4) is deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
FNF acid-d4
12352005
Isotope-Labeled Compounds
Others
Metabolism-protein/nucleotide metabolism
Metabolic Disease
CC(C)(OC1=C([2H])C([2H])=C(C(C2=CC=C(Cl)C=C2)=O)C([2H])=C1[2H])C(O)=O
C17H11D4ClO4
322.78
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-B0760S2/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Fenofibric acid-d4 (FNF acid-d4) is deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of
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