Fenspiride-d5 (hydrochloride)

Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride. Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist[1][2].

1246815-28-0

12352005

Adrenergic Receptor; Histamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Metabolism-protein/nucleotide metabolism

Endocrinology; Inflammation/Immunology

10 mM in DMSO

O=C1OC2(CN1)CCN(CC2)CCC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H].Cl

C15H16D5ClN2O2

301.82

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Lebedenko AA, Mal'tsev SV.
 .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.]
 Vestn Otorinolaringol. 2011; (4) :66-67.|[3]Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12 (6) :363-8.|[4]Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18 (108) :624-8.|[5]Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond) . 1995 Mar;88 (3) :325-30.|[6]Fenspiride

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0027S/

Isotope-Labeled Compounds

No Development Reported

H1 Receptor