Fenytoïne-d5

Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

5,5-Diphenylhydantoin-d5

12352005

Isotope-Labeled Compounds; Sodium Channel; Virus Protease

Anti-infection; Membrane Transporter/Ion Channel; Others

Cancer-programmed cell death

Neurological Disease; Cancer

O=C1NC(C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=CC=CC=C3)N1)=O

C15H7D5N2O2

257.30

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Assaggaf MA, et al. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2015 Jun;185 (6) :1588-99.|[3]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[4]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[5]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[6]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0448S2/

Isotope-Labeled Compounds

No Development Reported