FER Antilichaam [5D2C4 / 8D8C12]

FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

2241

P16591

P16591

Human

Ni-NTA purified truncated recombinant FER-His expressed in E. Coli strain BL21 (DE3) .

5D2C4 / 8D8C12

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

FER monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

FER

Fer (fps/fes related) tyrosine kinase

Homo sapiens

Li L. Cheng X. Ling HQ. Plant Mol Biol. 2004, Jan, 54 (1) :125-36.

Girault JA. Greengard P. Arch Neurol. 2004, May, 61 (5) :641-4.

Fan L. Di Ciano-Oliveira C. Weed SA. et al. Biochem J. 2004, Jun 1, 380 (Pt 2) :581-91.

TYK3, Feline encephalitis virus-related kinase FERFerT, TYK3, Pe1Fe3, Pe1Fe6, PPP1R74, Pe1Fe10, Pe1Fe13

ELISA, WB

97536202