Ferrocine A

Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12) . Ferrocin A can stably bind to nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections[1].

114550-08-2

12352005

Antibiotic; Bacterial; SARS-CoV

Anti-infection

COVID-19-anti-virus

Infection

O=C1OCC(C(NC2C(NCC(NC(C(C)C)C(NC(CO)C(NC3C(NC(C)C(NCC(NC(CCCN4[O-][Fe+3]56(O=C(C)N(CCC2)[O-]5)(O=C(C)N(CCC3)[O-]6)O=C4C)C(NC1)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(C/C=C/CCCCCC)=O

C51H82FeN13O19

1237.12

[1]Xia B, et al. Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking. Biomed J. 2021 Dec;44 (6 Suppl 1) :S15-S24.|[2]Katayama N, et al. Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo) . 1993 Jan;46 (1) :65-70.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14351/

Natural Products

No Development Reported