Ferroptosis-IN-21

Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal I/R injury by suppressing ferroptosis and directly scavenging peroxyl radicals. Ferroptosis-IN-21 displays broad-spectrum anti-ferroptotic efficacy across multiple inducers in renal tubular epithelial cells, with nanomolar potency and robust suppression of lipid Reactive Oxygen Species (ROS) . Ferroptosis-IN-21 significantly ameliorates renal I/R injury in mice, reducing histological damage, functional impairment, and inflammatory cytokine expression, while decreasing lipid peroxidation biomarkers such as 4-hydroxynonenal. Ferroptosis-IN-12 can be used for research in the field of ferroptosis-targeted drug development[1].

6640-50-2

1,2,3,4-Tetrahydroquinolin-8-ol; 8-hydroxy-1,2,3,4-tetrahydroquinoline

12352005

H302, H412

Ferroptosis; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

COVID-19-immunoregulation

Inflammation/Immunology

99.88

DMSO : ≥ 100 mg/mL

OC1=CC=CC2=C1NCCC2

C9H11NO

149.19

H302, H412

[1]Sheng XH, et al. Discovery of 8-hydroxy-tetrahydroquinoline ferroptosis inhibitors for the treatment of acute kidney injury. Bioorg Chem. 2025 Sep;164:108874.

Room Temperature

RT, protect from light

http://file.medchemexpress.com/batch_PDF/HY-W002942/Ferroptosis-IN-21-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported