FES-antilichaam [2E3G3 / 2G9G1]

FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

2242

P07332

P07332

Human

Ni-NTA purified truncated recombinant FES-His expressed in E. Coli strain BL21 (DE3) .

2E3G3 / 2G9G1

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

FES monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

FES

Feline sarcoma oncogene

Homo sapiens

Delfino FJ. Stevenson H. Smithgall TE. J Biol Chem. 2006, Mar 31, 281 (13) : 8829-35. Epub 2006 Feb 2.

Durfee WK. Rivard A. J Biomech Eng. 2005, Nov, 127 (6) :1014-9.

Vitenzon AS. Mironov EM. Petrushanskaya KA. Neurosci Behav Physiol. 2005, Sep, 35 (7) :709-14.

FPS, Proto-oncogene c-FesFPS

ELISA, WB, IHC

115502390