FFS-21

FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Murine FGF-21 is a 20.1 kDa protein containing 182 amino acid residues.

Fibroblast Growth Factor-21, FGFL

56636

Q9JJN1

NP_064397.1

NM_020013.4

Mouse

Mouse

MAYPIPDSSP LLQFGGQVRQ RYLYTDDDQD TEAHLEIRED GTVVGAAHRS PESLLELKAL KPGVIQILGV KASRFLCQQP DGALYGSPHF DPEACSFREL LLEDGYNVYQ SEAHGLPLRL PQKDSPNQDA TSWGPVRFLP MPGLLHEPQD QAGFLPPEPP DVGSSDPLSM VEPLQGRSPS YAS

< 0.1 ng/µg of protein (< 1EU/µg)

≥ 95% by SDS-PAGE gel and HPLC analyses

Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells.

182

Lyophilized

20.1 kDa

E. coli