FGD1 Antilichaam - C-terminaal gebied: Biotine (ARP31673 P050-Biotine)

FYVE, RhoGEF and PH domain containing 1

AAS, FGDY, MRXS16, ZFYVE3

2245

P98174

NP_004454

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human FGD1

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

FGD1 is supported by BioGPS gene expression data to be expressed in Raji

0.5 mg/ml

Cow: 86%; Dog: 86%; Horse: 79%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 79%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

107kDa

Lebel, R.R., et al., (2002) Clin. Genet. 61 (2), 139-145

Wet Ice

961

FGD1

FGD1

Rabbit

FYVE, RhoGEF and PH domain-containing protein 1

NM_004463

WMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT