FGF-18 (diervrij)

FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein.

FGF18; ZFGF5; FGF-18

8817

O76093

NP_003853.1

NM_003862

5q34

Human

Mouse, Rat, Human

AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR

< 0.01 ng/µg of protein (< 0.1 EU/µg)

≥ 95% by SDS-PAGE gel and HPLC analyses.

Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

173

Lyophilized

20.1 kDa

E. coli