FGF-21 (diervrij)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
FGF21
26291
Q9NSA1
NP_061986.1
NM_019113
19q13.1-qter
Human
Mouse
MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
< 0.01 ng/µg of protein (< 0.1 EU/µg)
≥ 95% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 0.3-0.6 μg/ml, in the presence of murine Klotho.
182
Lyophilized
19.5 kDa
E. coli
Beschrijving
FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth
Specificaties
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