FGF7p

FGF7p is a small molecule peptide and a potential bladder protector. FGF7p can activate downstream signaling pathways of FGFR2 in the urinary tract epithelium (pFRS2α, pAKT and pERK) . FGF7p alleviates cyclophosphamide induced apoptosis and tissue damage in urinary tract epithelial cells by activating AKT and its downstream anti apoptotic targets (pBAD, pS6/mTORC1) . FGF7p has the advantages of low cost, good stability, and high purity. FGF7p is commonly used in the study of inflammatory conditions[1].

2758194-43-1

12352209

Akt; Apoptosis; ERK; FGFR; mTOR

Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Inflammation/Immunology

O=C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(N)=O)C(NCC(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N

C95H138N26O28S

2124.33

[1]Narla ST, et al. FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide. Physiol Rep. 2022 Apr;10 (7) :e15241.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11162/

Peptides

No Development Reported

Akt; ERK; FGFR2; mTORC1