FGF8a / FGF8a eiwit

In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.

AIGF Protein; FGF-8 Protein; FGF8 Protein; HBGF-8 Protein; HH6 Protein; KAL6 Protein

NP_149355.1

Human

Human

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> 95 % as determined by SDS-PAGE.

Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 μg/mL.

183

Lyophilized or frozen liquid

20 mM Tris, 500 mM NaCl, pH 8.5.

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21.3 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

E.coli