FGFR1-Y307 Antilichaam

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

2260

P11362

P11362

Human

This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from human FGFR1.

Unconjugated

Primary Antibodies

Cancer, Neuroscience, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Predicted species reactivity based on immunogen sequence: Chicken, Mouse

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

92 kDa

Rabbit Ig

For WB starting dilution is: 1:1000

FGFR1

Fibroblast growth factor receptor 1

Homo sapiens

Turner, N., et al. Cancer Res. 70 (5) :2085-2094 (2010)

Chen, G., et al. Br. J. Cancer 102 (1) :188-195 (2010)

Kang, W., et al. J. Neurosci. 29 (46) :14571-14580 (2009)

Marzioni, D., et al. IntImmunopathol Pharmacol 22 (3) :627-638 (2009)

Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

WB

120046

Liquid