FGFR1/2 (fosfo Tyr463/466) Antilichaam

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

2260;2263

P11362; P21802

NP_075598.2

Human, Mouse

FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p) -E-L) derived from Human FGFR1/2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

91 kDa

IgG

The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466.

FGFR1, FGFR2

Fibroblast growth factor receptor 1, fibroblast growth factor receptor 2

Homo sapiens

Itoh N., Biochem. Biophys. Res. Commun. 169:680-685 (1990) .

Dionne C.A., EMBO J. 9:2685-2692 (1990) .

Johnson D.E., Mol. Cell. Biol. 10:4728-4736 (1990) .

BFGFR, CEK, FLG, CD331, FLT2

WB

291327489

Liquid