FGFR3 Antilichaam

Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. The gene is mapped to the HD region on chromosome 4p16.3. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL

P22607

Human, Rat

An amino acid sequence from the N-terminus of human Fibroblast growth factor receptor 3 (RQRLTQRVLCHFSVRVTDAP) was used as the immunogen for this FGFR3 antibody.

WB, IHC-P, ICC

Antigen affinity

Antigen affinity purified

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

This FGFR3 antibody is available for research use only.

After reconstitution, the FGFR3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

The stated application concentrations are suggested starting amounts. Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of FGFR3 antibody and Lane 1: U87; 2: SGC cell lysate. Predicted molecular weight: 87-135 kDa depending on glycosylation level.