FHIT Antilichaam

FHIT is member of the histidine triad gene family and is a diadenosine involved in purine metabolism (1) . FHIT is also thought to be a tumor suppressor gene and is involved in multiple apoptotic pathways (1,2) . The FHIT gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene (3) . Aberrant transcripts from this gene have been found in multiple carcinomas (4) .

2272

P49789

NP_002003

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

FHIT Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (88%), Rat: (72%)

FHIT Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FHIT antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

FHIT antibody is human and mouse reactive.

FHIT

Cat. No. 17-001 - HeLa Cell Slide

Fragile histidine triad

Homo sapiens

Barnes LD, Garrison PN, Siprashvili Z, et al. Fhit, a putative tumor suppressor in humans, is a dinucleotide 5',5'''-P1, P3-triphosphate hydrolase. Biochemistry 1996; 35:11529-35.

Wali A. FHIT: doubts are clear now. ScientificWorldJournal 2010; 10:1142-51.

Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t (3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84:587-97.

Drusco A, Pekarsky Y, Costinean S, et al. Common fragile site tumor suppressor genes and corresponding mouse models of cancer. J. Biomed. Biotechnol.2011; Epub 2010 Dec 29.

FHIT Antibody : FRA3B, AP3AaseAP3A hydrolase, AP3Aase

ELISA, WB, IF

4503719

Liquid