Fibulin5 Antilichaam [3F10A5 / 3F8A12]

Fibulin 5 (FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.

10516

Q9UBX5

Q9UBX5

Human

Ni-NTA purified truncated recombinant Fibulin 5 expressed in E. Coli strain BL21 (DE3) .

3F10A5 / 3F8A12

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Fibulin 5 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

FBLN5

Fibulin 5

Homo sapiens

Wen Wang , Scott A. LeMaire, Li Chen. Surgery. 2005 Aug;138 (2) :352-9

K. Kadoya, T. Sasaki, G. Kostka. Br J Dermatol. 2005 Sep;153 (3) :607-123.

Michael J. Lee, Nakshatra K. Roy, Jon E. Mogford. J Am Coll Surg. 2004 Sep;199 (3) :403-10.

DANCE, UNQ184/PRO210, Developmental arteries and neural crest EGF-like protein, FIBL-5, EVEC, UP50, ADCL2, ARMD3, DANCE, ARCL1A

ELISA, WB, IHC

12643876