FK 633

FK 633 (FR-144633) is a fibrinogen inhibitor and peptide mimetic GPIIbIIa receptor antagonist. FK 633 has anti-platelet and anti-thrombotic effects. FK 633 inhibits ADP-, collagen-, thrombin-, and PAF-induced platelet aggregation with IC50 values of 103, 87, 98, and 239 nM, respectively[1][2].

147865-49-4

FR-144633

12352005

Integrin; Thrombin

Cytoskeleton; Metabolic Enzyme/Protease

Cardiovascular Disease

CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(CCCOC1=CC=C(C(N)=N)C=C1)=O)=O

C20H28N4O7

436.46

[1]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50. |[2]Aoki T, et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res. 1996 Feb 15;81 (4) :439-50.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19175/

Reference compound1

Phase 2