FKBP15 Antilichaam

FKBP15 Antibody: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

23307

Q5T1M5

NP_056073

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

FKBP15 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

FKBP15 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FKBP15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

FKBP15

FK506 binding protein 15, 133kDa

Homo sapiens

Nakajima O, Nakamura F, Yamashita N, et al. FKBP133: A novel mouse FK506-binding protein homolog alters growth cone morphology. Biochem. Biophys. Res. Comm.2006; 346:140-9.

Snyder SH, Lai MM, and Burnett PE. Immunophilins in the nervous system. Neuron1998; 21:283-94.

Viklund I-M, Aspenstrom P, Meas-Yedid V, et al. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. Exp. Cell Res.2009; 315:1040-52.

FKBP15 Antibody: FKBP133, PPP1R76, KIAA0674, FK506-binding protein 15, 133 kDa FK506-binding protein, FKBP-15

ELISA, WB, IHC-P, IF

150010552

Liquid