FKBP1B Recombinant eiwit

Source : Escherichia Coli. FKBP1B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-108) and having a molecular mass of 14.2kDa.FKBP1B is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus) . FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.

Peptidyl-prolyl cis-trans isomerase FKBP1B||PPIase FKBP1B||12.6 kDa FK506-binding protein||12.6 kDa FKBP||FKBP-12.6||FK506-binding protein 1B||FKBP-1B||Immunophilin FKBP12.6||Rotamase||h-FKBP-12||FKBP1B||FKBP12.6||FKBP1L||FKBP9||OTK4.

Greater than 90.0% as determined by SDS-PAGE analysis.

The FKBP1B solution (0.25mg/mL) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.

Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE.