FKBP5 Antilichaam - C-terminalgebied: Biotine (ARP54713_P050-Biotine)

FK506 binding protein 5

P54, AIG6, FKBP51, FKBP54, PPIase, Ptg-10

2289

Q13451

NP_004108

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP5

FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

LRRC40; CXorf57; EGLN1; AGO2; CACYBP; CHORDC1; AGO1; KIAA1279; NUDCD3; GLMN; CDC37; SUGT1; PTGES3; NUDC; AHSA1; DNAJB6; AURKB; IKBKG; IRS4; TUBA1A; TTC4; PYGL; PDCD2; CDK11A; HGH1; C14orf80; MCMBP; PNPLA2; ANKMY2; CDC37L1; MCM4; ILK; HSP90AB1; HSP90AA1; H

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

51kDa

Lekman, M., (2008) Biol. Psychiatry 63 (12), 1103-1110

Wet Ice

457

FKBP5

FKBP5

Rabbit

Peptidyl-prolyl cis-trans isomerase FKBP5

NM_004117

CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFE