FKHR (fosfo Ser319) Antilichaam

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

2308

Q12778

NP_002006.2

Human, Mouse

FKHR (Phospho-Ser319) antibody was raised against a peptide sequence around phosphorylation site of serine 319 (T-S-S (p) -N-A) derived from Human FKHR/FOXO1A.

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

78 - 82 kDa

This antibody detects endogenous level of FKHR only when phosphorylated at serine 319.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

FOXO1

Forkhead box O1

Homo sapiens

Rena G, et al. (2002) EMBO J 21 (9) : 2263-2271. Woods YL, et al. (2001) Biochem J355 (Pt 3) : 597-607. Rena G, et al. (2001) Biochem J 354 (Pt 3) : 605-612.

FKH1, FKHR, FOXO1A, MEK2, MKK2, PRKMK2, FOXO1

WB, IHC, IF

9257222

Liquid