Flecaïnide (hydrochloride) (standaard)

Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2) . Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) [1][2][3].

57415-44-8

12352005

Potassium Channel; Sodium Channel

Membrane Transporter/Ion Channel

Cardiovascular Disease

O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.[H]Cl

C17H21ClF6N2O3

450.80

[1]Kuroda Y, et al. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochem Biophys Rep. 2017 Jan 11;9:245-256.|[2]Watanabe H, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009 Apr;15 (4) :380-3.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W010950AR/

Reference Standards