FLI1 Antilichaam

The Friend leukemia virus integration 1 (FLI1) protein is a transcription factor containing an ETS DNA-binding domain and is highly expressed in hematopoietic cell lineages and vascular endothelial cells (1) . FLI1 plays important roles in megakaryocytic differentiation (2) and vascular homeostasis (3) . The FLI1 gene can undergo a t (11;22) (q24; q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. (4) . Abnormal expression of FLI1 can be used as an adverse prognostic indicator for acute myeloid leukemia (5) .

2313

Q01543

NP_002008

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

FLI1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

FLI1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FLI1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

FLI1 antibody is human, mouse and rat reactive. At least four isoforms of FLI1 are known to exist; this antibody will detect all four.

FLI1

Cat. No. 17-001 - HeLa Cell Slide

Fli-1 proto-oncogene, ETS transcription factor

Homo sapiens

Hollenhorst PC, Jones DA, and Graves BJ. Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nuc. Acids Res. 2004; 32:5693-702.

Spyropoulos DD, Pharr PN, Lavenburg KR, et al. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol. Cell Biol. 2000; 20:5643-52.

Asano Y, Stawski L, Hant F, et al. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am. J. Pathol. 2010; 176:1983-98.

May WA, Gishizky ML, Lessnick SL, et al. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc. Natl. Acad. Sci. USA 1993; 90:5752-6. 5. Kornblau SM, Qiu YH, Zhang N, et al. Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Blood 2011; 118:5604-12.

FLI1 Antibody: EWSR2, SIC-1, BDPLT21

ELISA, WB, IF

7110593

Liquid