Flindersine

Flindersine is an antidiabetic and antioxidant agent. Flindersine can result in a decline of blood glucose levels in rats. Flindersine also reduces the body weight gain, plasma insulin concentration, urea, creatinine, total cholesterol, triglycerides and free fatty acids levels in vivo. Flindersine enhances the phophotylation of GLUT4, AMPK, and PPARγ in adipose tissues and skeletal muscles[1].

523-64-8

12352005

H302-H315-H319-H335

AMPK; GLUT; PPAR; Reactive Oxygen Species (ROS)

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Metabolism-sugar/lipid metabolism

Metabolic Disease

O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2

C14H13NO2

227.26

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Irudayaraj, S. S., et al., (2022) . Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. Journal of ethnopharmacology, 285, 114883.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W984782/

Natural Products

No Development Reported