FLIP-antilichaam [Dave-2]

FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

8837

O15519

2253679

Human, Mouse

Recombinant human FLIP (aa 1-480) .

Dave-2

Unconjugated

Primary Antibodies

Apoptosis, Cancer

1 mg/ml

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

None

Blue Ice

Stable for at least 1 year after receipt when stored at -20˚ C.

IgG2a

Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP.

Immunoprecipitation: (1-2ug/ml) . Western Blot: (1-5ug/ml) . Optimal conditions must be determined individually for each application.

CFLAR

CASP8 and FADD-like apoptosis regulator

Homo sapiens

I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1

IP, WB

AAC51622

Liquid