Florfenicol-13C6

Florfenicol-13C6 (SCH-25298-13C6) is 13C labeled Florfenicol. Florfenicol ((-) -Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions[6][7].

SCH-25298-13C6

12352211

Antibiotic; Bacterial; Isotope-Labeled Compounds

Anti-infection; Others

COVID-19-immunoregulation

Infection; Inflammation/Immunology

ClC(Cl)C(N[C@H](CF)[C@@H]([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)S(C)(=O)=O)O)=O

C6 13C6H14Cl2FNO4S

364.17

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hu D, et al. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017 Oct 19;7 (1) :13554.|[3]Arslan P, et al. In vitro effects of erythromycin and florfenicol on primary cell lines of Unio crassus and Cyprinus carpio. Environ Sci Pollut Res Int. 2021 Sep;28 (35) :48408-48416.|[4]Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11:213. |[5]Wang X, et al. Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway. Poult Sci. 2022 Nov;101 (11) :102152.|[6]Lis M, et al. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens. Pol J Vet Sci. 2019 Dec;22 (4) :481-487. |[7]Xinxin C, et al. Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. Clin Immunol. 2011 Feb;138 (2) :231-8. |[8]Shuang G, et al. Immunosuppressive activity of florfenicol on the immune responses in mice. Immunol Invest. 2011;40 (4) :356-66.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1374S2/

Isotope-Labeled Compounds

No Development Reported