Floxuridine-13C,15N2

Floxuridine-13C,15N2 (5-Fluorouracil 2'-deoxyriboside-13C,15N2) is the 13C- and 15N-labeled labeled Floxuridine. Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly (ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis[1][2]. Floxuridine has antiviral effects against HSV and CMV[3].

5-Fluorouracil 2'-deoxyriboside-13C,15N2

12352005

Apoptosis; Bacterial; CMV; DNA/RNA Synthesis; HSV; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Others

Cancer-programmed cell death

Cancer

O[C@H]1C[C@@H](O[C@@H]1CO)[15N](C=C2F)[13C]([15NH]C2=O)=O

C8 13CH11F 15N2O5

249.17

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W766548/

Isotope-Labeled Compounds

No Development Reported