FLT1-eiwit (C-human IgG1-Fc, mens)

FLT1

FLT, FLT-1, FRT, VEGFR-1, VEGFR1

C-human IgG1-Fc

< 1.0 EU per μg protein as determined by the LAL method.

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

1. Measured by its binding ability in a functional ELISA. Immobilized human VEGFR1-Fc (Cat:10136-H02H) at 10μg/mL (100μL/well) can bind biotinylated human VEGF165 (Cat:11066-HNAH), the EC50 of biotinylated human VEGF165 is 10-40 ng/mL. 2. Measured by its ability to inhibit VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC) . The ED50 for this effect is typically 20-100 ng/mL in the presence of 10 ng/mL rhVEGF165.

Met1-Ile328

The recombinant human FLT1 consists 543 amino acids and predicts a molecular mass of 61.1 kDa.

Human