FLT3 Antilichaam

FLT3 Antibody: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.

2322

P36888

NP_004110

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

FLT3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

FLT3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

FLT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

109 kDa

IgG

At least three isoforms of FLT3 are known to exist; this antibody will detect all isoforms.

FLT3

Cat. No. 10-401 - Human Kidney Tissue Slide

Fms-related tyrosine kinase 3

Homo sapiens

Rosnet O, Schiff C, Pebusque MJ, et al. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 1993; 82:1110-9

Yokoa S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. Leukemia 1997; 11:1605-9.

Takahashi S. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. J. Hematol. and Oncol. 2011; 4:13.

FLT3 Antibody: FLK2, STK1, CD135, FLK-2, FLK2, Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor

ELISA, WB, IF

121114304

Liquid