FLT3 D835Y Recombinant humaan actief eiwit Kinase

FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays important roles in cell survival, proliferation, and differentiation during normal hematopoiesis. FLT3 is one of the most frequently mutated genes in acute myeloid leukemia (AML) . FLT3 D835Y is the most frequent kinase domain mutation, converting aspartic acid to tyrosine. FLT3 D835Y Recombinant Human Active Protein Kinase is a recombinant FLT3 D835Y protein that can be used to study FLT3 D835Y-related functions[1].

12352211

FLT3

Protein Tyrosine Kinase/RTK

Cancer

[FLT3D835YRecombinantHumanActiveProteinKinase]

[1]Bailey E, et al. FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice. Proc Natl Acad Sci U S A. 2013 Dec 24;110 (52) :21113-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-E70723/

Enzyme

No Development Reported