Fluacrypyrim

Fluacrypyrim, a Miticide, is a STAT3 inhibitor. Fluacrypyrim significantly increases the protein tyrosine phosphatases (PTPs) activity. Fluacrypyrim inhibits the growth of leukemia cells by a predominant G1 arrest with significant decrease of the protein and mRNA levels of cyclin D1. Fluacrypyrim selectively inhibits STAT3 signaling, inducing growth arrest and apoptosis in STAT3-dependent cancer cells. Fluacrypyrim mitigates IR-induced hematopoietic system injury mainly by preventing apoptosis in the HSCs. Fluacrypyrim demonstrates significant analgesic and anti-inflammatory effects by inhibiting uterine smooth muscle contraction and inflammatory responses[1][2][3][4].

229977-93-9

12352005

H410

Apoptosis; MDM-2/p53; Parasite; Phosphatase; STAT

Anti-infection; Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

COVID-19-immunoregulation

Cancer; Infection; Inflammation/Immunology; Neurological Disease

COC(/C(C1=C(C=CC=C1)COC2=NC(OC(C)C)=NC(C(F)(F)F)=C2)=C/OC)=O

C20H21F3N2O5

426.39

P273-P391-P501

[1] Zhang X, et al. Fluacrypyrim Protects Hematopoietic Stem and Progenitor Cells against Irradiation via Apoptosis Prevention. Molecules. 2024 Feb 9;29 (4) :816. |[2]Yu ZY, et al. Fluacrypyrim, a novel STAT3 activation inhibitor, induces cell cycle arrest and apoptosis in cancer cells harboring constitutively-active STAT3. Int J Cancer. 2010 Sep 1;127 (6) :1259-70. |[3]Li Z, et al. Flucrypyrim, a novel uterine relaxant, has antinociceptive and anti-inflammatory effects in vivo. Sci Rep. 2017 Feb 21;7:42040. |[4]Sakuda S, et al. Inhibitory effects of respiration inhibitors on aflatoxin production. Toxins (Basel) . 2014 Mar 26;6 (4) :1193-200.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W414644/

Reference compound2

No Development Reported