Flucofuron

Flucofuron exhibits high efficacy against trophozoites of both N. fowleri strains (ATCC 30808 : IC50 = 2.58 μM and ATCC 30215: IC50 = 2.47 μM), being even active against the resistant cyst stage (IC50 = 0.88 μM) . Flucofuron can induce cell apoptosis. Flucofuron can be used for the researches of infection and inflammation, such as Primary amoebic meningoencephalitis (PAM) [1].

370-50-3

12352005

H302, H315, H319, H335

Apoptosis

Apoptosis

COVID-19-immunoregulation

Infection; Inflammation/Immunology

99.75

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)NC2=CC=C(Cl)C(C(F)(F)F)=C2

C15H8Cl2F6N2O

417.13

H302, H315, H319, H335

[1]Chao-Pellicer J, et al. Flucofuron as a Promising Therapeutic Agent against Brain-Eating Amoeba. ACS Infect Dis. 2024 Jun 14;10 (6) :2063-2073.

Room Temperature

4°C (Powder, protect from light, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-I0673/

Reference compound2

No Development Reported