Fludioxonil-13C3

Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].

1185003-07-9

CGA-173506-13C3

12352005

Apoptosis; Fungal; Isotope-Labeled Compounds

Anti-infection; Apoptosis; Others

COVID-19-immunoregulation

Cancer; Infection

FC1(OC2=C([13C]3=CNC=[13C]3[13C]#N)C=CC=C2O1)F

C9 13C3H6F2N2O2

251.16

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yabing Duan, et al. effect of phenylpyrrole fungicide fludioxonil on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pesticide Biochemistry and Physiology Volume 106, Issues 1-2, May-June 2013, Pages 61-67.|[3]Ryeo-Eun Go, et al. Fludioxonil induced the cancer growth and metastasis via altering epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in cellular and xenografted breast cancer models. Environ Toxicol. 2017 Apr;32 (4) :1439-1454. |[4]Imen Graiet, et al. Fludioxonil, a phenylpyrrol pesticide, induces Cytoskeleton disruption, DNA damage and apoptosis via oxidative stress on rat glioma cells. Food Chem Toxicol. 2022 Dec:170:113464.|[5]Su-Min Seong, et al. Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models. Environ Toxicol. 2024 May;39 (5) :2993-3002.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W021040S/

Isotope-Labeled Compounds

No Development Reported