FluoSiteTM Anti-STEAP1 Antilichaam, PE-Labeled

STEAP1 (six transmembrane epithelial antigen of the prostate 1), also called STEAP, belongs to the STEAP family of metalloproteinases, which are involved in iron and copper regulation and other processes. It is a cell surface protein expressed in several types of cancer, most notably prostate cancer where STEAP1 was identified as a cancer specific cell-surface antigen. The upregulation of STEAP1 is linked to promotion of cancer cell proliferation and metastatic transformation and higher STEAP expression levels are correlated with poor survival. The differential expression of STEAP1 between cancer cells and normal tissue makes STEAP1 a promising target for antibody-drug-conjugate (ADC) development. The use of STEAP1 CAR (chimeric antigen receptor) -T cell therapy combined with tumor-localized IL-12 therapy is also under study for the treatment of prostate cancer.

This anti-STEAP1 (six transmembrane epithelial antigen of the prostate 1) antibody is a purified monospecific recombinant antibody, which is labeled with R-Phycoerythrin (PE) . This antibody has been tested by flow cytometry for binding to human STEAP1 on the surface of STEAP1 HEK293 Cell Line (BPS Bioscience#82749) .FluoSite™is a tag-based method for site-specific conjugation of antibodies with fluorophores, ensuring the labeling site is far from the antigen-binding domain to preserve antibody functionality. This precise, consistent labeling ensures the homogeneity of the labeled antibody preparation, making it ideal for flow cytometry and other high-sensitivity applications.

Q9UHE8

This antibody recognizes human STEAP1. It has not been tested in other species.

PE is an oligomeric protein complex (270 kDa) from red algae that exhibits intensely bright red-orange fluorescence with excitation peak at 566 nm and an emission peak at 574 nm. The complex consists of six heterodimers, α subunit (18 kDa) and β-subunit (20 kDa), and an additional γ-subunit (34 kDa) .

Useful for studying the expression of human STEAP1 on the cell surface by flow cytometry.

Protein A affinity chromatography from HEK293 supernatant.

≥ 90%

Aqueous buffer solution.

+4°C (Gel Packs)

At least 6 months at +4°C. Protect from prolonged exposure to light. DO NOT FREEZE. The antibody solution should be stored undiluted between +2°C and +8°C.

8 mM Phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.