Fluoxetine-d6

Fluoxetine-d6 (LY-110140 (free base) -d6) is deuterium labeled Fluoxetine. Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

2319722-07-9

LY-110140 (free base) -d6

12352005

Autophagy; Isotope-Labeled Compounds; Serotonin Transporter

Autophagy; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

FC(F)(F)C(C=C1)=CC=C1OC(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])([2H])CCNC

C17H12D6F3NO

315.36

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl) . 2002 Apr;160 (4) :353-61|[3]Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23 (3) :250-62.|[4]Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28 (6) :1374-84.|[5]Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? Behav Brain Res. 2017 Jan 15;317:62-70.|[6]Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56 (8) :570-80.|[7]Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28 (9) :1562-71

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0102S/

Isotope-Labeled Compounds

No Development Reported