Flupirtine-d6 (hydrochloride)

Flupirtine-d6 (D 9998-d6) hydrochloride is the deuterium labeled Flupirtine hydrochloride. Flupirtine hydrochloride (D 9998 hydrochloride) is a selective neuropotassium channel opener with analgesic activity. Flupirtine hydrochloride is used to inhibit a variety of pain conditions, including chronic musculoskeletal pain, migraines, and neuralgia. Flupirtine hydrochloride has antidepressant and antioxidant properties and may increase the analgesic effect in combination therapy with morphine. Flupirtine hydrochloride relieves abnormally increased muscle tension and has a muscle relaxant effect. Flupirtine hydrochloride is clinically superior to other drugs, such as tramadol and pantoxan, plus its side effects are better tolerated. Flupirtine hydrochloride has a significant effect on inhibiting neural hyperexcitability and therefore exhibits inhibitory potential in various pain states[1].

D 9998-d6 (hydrochloride)

12352005

IGluR; Isotope-Labeled Compounds; Potassium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Inflammation/Immunology

NC1=NC(NC([2H])([2H])C2=C([2H])C([2H])=C(F)C([2H])=C2[2H])=CC=C1NC(OCC)=O.Cl

C15H12D6ClFN4O2

346.82

[1]Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106 (9-10) :857-67.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W709349S/

Isotope-Labeled Compounds

No Development Reported