Fmoc-PEG2-Val-Cit-PAB-OH
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine for use in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
2055024-59-2
12352203
H302-H315-H319-H335
ADC Linker
Antibody-drug Conjugate/ADC Related
Cancer
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O
C40H52N6O9
760.88
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W800621/
ADC Related
No Development Reported
Beschrijving
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic
Specificaties
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