Fmoc-PEG4-Val-Cit-PAB-OH
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2055024-58-1
ADC Linker
Antibody-drug Conjugate/ADC Related
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.
C(OC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)[C@H](C)C)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
C44H60N6O11
848.981
Ice Packs
-20°C
Beschrijving
Fmoc-PEG4-Val-Cit-PAB-OH Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
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